Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 1 group I member 2
Ligand
BDBM75502
Substrate
n/a
Meas. Tech.
Luminescence-based counterscreen for activators of the Aryl Hydrocarbon Receptor (AHR): cell-based high throughput dose response screening assay for activators of the Pregnane X Receptor (PXR)
EC50
>116159±n/a nM
Citation
 PubChem, PC Luminescence-based counterscreen for activators of the Aryl Hydrocarbon Receptor (AHR): cell-based high throughput dose response screening assay for activators of the Pregnane X Receptor (PXR) PubChem Bioassay (2010)[AID] 
Target
Name:
Nuclear receptor subfamily 1 group I member 2
Synonyms:
NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1
Type:
Nuclear receptor
Mol. Mass.:
49774.77
Organism:
Homo sapiens (Human)
Description:
O75469
Residue:
434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
  
Inhibitor
Name:
BDBM75502
Synonyms:
6-[(E)-({3-[(4-fluorobenzoyl)amino]benzoyl}hydrazono)methyl]-2,3-dimethoxybenzoic acid | 6-[[[3-[(4-fluorobenzoyl)amino]benzoyl]hydrazinylidene]methyl]-2,3-dimethoxybenzoic acid | 6-[[[3-[(4-fluorobenzoyl)amino]benzoyl]hydrazono]methyl]-2,3-dimethoxy-benzoic acid | 6-[[[3-[(4-fluorophenyl)carbonylamino]phenyl]carbonylhydrazinylidene]methyl]-2,3-dimethoxy-benzoic acid | 6-[[[[3-[[(4-fluorophenyl)-oxomethyl]amino]phenyl]-oxomethyl]hydrazinylidene]methyl]-2,3-dimethoxybenzoic acid | MLS000685633 | SMR000312597 | cid_16194515
Type:
Small organic molecule
Emp. Form.:
C24H20FN3O6
Mol. Mass.:
465.4305
SMILES:
COc1ccc(C=NNC(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2)c(C(O)=O)c1OC
Structure:
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