Reaction Details Report a problem with these data
Target
Intestinal-type alkaline phosphatase
Ligand
BDBM75619
Substrate
n/a
Meas. Tech.
Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay
EC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM75619
Synonyms:
2H-1-benzopyran-3-carboxylic acid [1-(cyclopentylamino)-1-oxobutan-2-yl] ester | 2H-Chromene-3-carboxylic acid 1-cyclopentylcarbamoyl-propyl ester | 2H-chromene-3-carboxylic acid 1-(cyclopentylcarbamoyl)propyl ester | MLS000560228 | SMR000173685 | [1-(cyclopentylamino)-1-oxidanylidene-butan-2-yl] 2H-chromene-3-carboxylate | [1-(cyclopentylamino)-1-oxobutan-2-yl] 2H-chromene-3-carboxylate | cid_3230498
Type:
Small organic molecule
Emp. Form.:
C19H23NO4
Mol. Mass.:
329.3902
SMILES:
CCC(OC(=O)C1=Cc2ccccc2OC1)C(=O)NC1CCCC1 |t:6|
Structure:
Search PDB for entries with ligand similarity: