Reaction Details Report a problem with these data
Target
Intestinal-type alkaline phosphatase
Ligand
BDBM75641
Substrate
n/a
Meas. Tech.
Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay
EC50
6030±n/a nM
Citation
 PubChem, PC Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM75641
Synonyms:
3-(1,3-benzodioxol-5-yl)-N'-[(E)-(6-ketocyclohexa-2,4-dien-1-ylidene)methyl]-1H-pyrazole-5-carbohydrazide | 3-(1,3-benzodioxol-5-yl)-N'-[(E)-(6-oxidanylidenecyclohexa-2,4-dien-1-ylidene)methyl]-1H-pyrazole-5-carbohydrazide | 3-(1,3-benzodioxol-5-yl)-N'-[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-1H-pyrazole-5-carbohydrazide | 3-(1,3-benzodioxol-5-yl)-N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-1H-pyrazole-5-carbohydrazide | 5-Benzo[1,3]dioxol-5-yl-2H-pyrazole-3-carboxylic acid [1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide | MLS000807057 | SMR000414871 | cid_16465914
Type:
Small organic molecule
Emp. Form.:
C18H14N4O4
Mol. Mass.:
350.3282
SMILES:
Oc1ccccc1C=NNC(=O)c1cc(n[nH]1)-c1ccc2OCOc2c1 |w:8.9|
Structure:
Search PDB for entries with ligand similarity: