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Target
Intestinal-type alkaline phosphatase
Ligand
BDBM75675
Substrate
n/a
Meas. Tech.
Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay
EC50
14300±n/a nM
Citation
 PubChem, PC Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM75675
Synonyms:
1-[2-(3,4-dichlorophenyl)ethanoylamino]-3-(oxolan-2-ylmethyl)thiourea | 1-[[2-(3,4-dichlorophenyl)-1-oxoethyl]amino]-3-(2-oxolanylmethyl)thiourea | 1-[[2-(3,4-dichlorophenyl)acetyl]amino]-3-(oxolan-2-ylmethyl)thiourea | 1-[[2-(3,4-dichlorophenyl)acetyl]amino]-3-(tetrahydrofurfuryl)thiourea | MLS001035791 | SMR000666347 | cid_2954804
Type:
Small organic molecule
Emp. Form.:
C14H17Cl2N3O2S
Mol. Mass.:
362.275
SMILES:
Clc1ccc(CC(=O)NNC(=S)NCC2CCCO2)cc1Cl
Structure:
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