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Target
Intestinal-type alkaline phosphatase
Ligand
BDBM75733
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule inhibitors of human intestinal alkaline phosphatase via a luminescent assay
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of human intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM75733
Synonyms:
3-(4-Bromo-phenyl)-5-thiophen-2-yl-3H-thieno[2,3-d]pyrimidin-4-one | 3-(4-bromophenyl)-5-(2-thienyl)thieno[2,3-d]pyrimidin-4-one | 3-(4-bromophenyl)-5-thiophen-2-yl-4-thieno[2,3-d]pyrimidinone | 3-(4-bromophenyl)-5-thiophen-2-yl-thieno[2,3-d]pyrimidin-4-one | 3-(4-bromophenyl)-5-thiophen-2-ylthieno[2,3-d]pyrimidin-4-one | MLS000552776 | SMR000146291 | cid_1909422
Type:
Small organic molecule
Emp. Form.:
C16H9BrN2OS2
Mol. Mass.:
389.289
SMILES:
Brc1ccc(cc1)-n1cnc2scc(-c3cccs3)c2c1=O
Structure:
Search PDB for entries with ligand similarity: