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Target
Intestinal-type alkaline phosphatase
Ligand
BDBM75734
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule inhibitors of human intestinal alkaline phosphatase via a luminescent assay
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of human intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM75734
Synonyms:
5-cyano-6-(2-methoxyphenoxy)-2-methyl-3-pyridinecarboxylic acid methyl ester | 5-cyano-6-(2-methoxyphenoxy)-2-methyl-nicotinic acid methyl ester | MLS000326003 | SMR000170138 | cid_1471663 | methyl 5-cyano-6-(2-methoxyphenoxy)-2-methyl-pyridine-3-carboxylate | methyl 5-cyano-6-(2-methoxyphenoxy)-2-methylnicotinate | methyl 5-cyano-6-(2-methoxyphenoxy)-2-methylpyridine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C16H14N2O4
Mol. Mass.:
298.2934
SMILES:
COC(=O)c1cc(C#N)c(Oc2ccccc2OC)nc1C
Structure:
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