Reaction Details Report a problem with these data
Target
Intestinal-type alkaline phosphatase
Ligand
BDBM75667
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule inhibitors of human intestinal alkaline phosphatase via a luminescent assay
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of human intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM75667
Synonyms:
2-(7-fluoranyl-4-oxidanylidene-pyrrolo[1,2-a]quinoxalin-5-yl)-N-[2-(4-methylpiperazin-1-yl)ethyl]ethanamide | 2-(7-fluoro-4-keto-pyrrolo[1,2-a]quinoxalin-5-yl)-N-[2-(4-methylpiperazino)ethyl]acetamide | 2-(7-fluoro-4-oxo-5-pyrrolo[1,2-a]quinoxalinyl)-N-[2-(4-methyl-1-piperazinyl)ethyl]acetamide | 2-(7-fluoro-4-oxopyrrolo[1,2-a]quinoxalin-5-yl)-N-[2-(4-methylpiperazin-1-yl)ethyl]acetamide | MLS001117041 | SMR000627119 | cid_22522721
Type:
Small organic molecule
Emp. Form.:
C20H24FN5O2
Mol. Mass.:
385.4353
SMILES:
CN1CCN(CCNC(=O)Cn2c3cc(F)ccc3n3cccc3c2=O)CC1
Structure:
Search PDB for entries with ligand similarity: