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Target
Intestinal-type alkaline phosphatase
Ligand
BDBM75771
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule inhibitors of human intestinal alkaline phosphatase via a luminescent assay
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of human intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM75771
Synonyms:
MLS001236645 | N-[2-(2,4-dimethylanilino)-2-keto-ethyl]-4-methyl-N-tosyl-piperazine-1-carboxamide | N-[2-(2,4-dimethylanilino)-2-oxoethyl]-4-methyl-N-(4-methylphenyl)sulfonyl-1-piperazinecarboxamide | N-[2-(2,4-dimethylanilino)-2-oxoethyl]-4-methyl-N-(4-methylphenyl)sulfonylpiperazine-1-carboxamide | N-[2-[(2,4-dimethylphenyl)amino]-2-oxidanylidene-ethyl]-4-methyl-N-(4-methylphenyl)sulfonyl-piperazine-1-carboxamide | SMR000812698 | cid_18580923
Type:
Small organic molecule
Emp. Form.:
C23H30N4O4S
Mol. Mass.:
458.574
SMILES:
CN1CCN(CC1)C(=O)N(CC(=O)Nc1ccc(C)cc1C)S(=O)(=O)c1ccc(C)cc1
Structure:
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