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Target
Furin
Ligand
BDBM60407
Substrate
n/a
Meas. Tech.
High throughput fluorescence intensity-based biochemical assay to screen for small molecule inhibitors of Furin:Concentration-response Confirmation Assays
IC50
>50000±n/a nM
Citation
 PubChem, PC High throughput fluorescence intensity-based biochemical assay to screen for small molecule inhibitors of Furin:Concentration-response Confirmation Assays PubChem Bioassay (2010)[AID] 
Target
Name:
Furin
Synonyms:
FUR | FURIN | FURIN_HUMAN | Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA | PACE | PCSK3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
86676.01
Organism:
Homo sapiens (Human)
Description:
P09958
Residue:
794
Sequence:
MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL
  
Inhibitor
Name:
BDBM60407
Synonyms:
(5Z)-5-[[4-(dimethylamino)anilino]methylene]-1-(o-tolyl)barbituric acid | (5Z)-5-[[4-(dimethylamino)anilino]methylidene]-1-(2-methylphenyl)-1,3-diazinane-2,4,6-trione | (5Z)-5-[[[4-(dimethylamino)phenyl]amino]methylidene]-1-(2-methylphenyl)-1,3-diazinane-2,4,6-trione | MLS000105663 | SMR000102641 | cid_5310822
Type:
Small organic molecule
Emp. Form.:
C20H20N4O3
Mol. Mass.:
364.3978
SMILES:
CN(C)c1ccc(cc1)N=Cc1c(O)n(-c2ccccc2C)c(=O)[nH]c1=O |w:9.9,(3.08,3.47,;4.41,4.24,;4.41,5.78,;5.75,3.47,;7.08,4.24,;8.41,3.47,;8.41,1.93,;7.08,1.16,;5.75,1.93,;9.75,1.16,;11.08,1.93,;12.42,1.16,;12.42,-.39,;11.08,-1.16,;13.75,-1.16,;13.75,-2.7,;15.08,-3.47,;15.08,-5.01,;13.75,-5.78,;12.42,-5.01,;12.42,-3.47,;11.08,-2.7,;15.08,-.39,;16.42,-1.16,;15.08,1.16,;13.75,1.93,;13.75,3.47,)|
Structure:
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