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Reaction Details
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TargetAngiotensin II receptor
LigandBDBM67184
Substrate/Competitorn/a
Meas. Tech.Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor
IC50 15944±3731 nM
Citation PubChem, PC Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor PubChem Bioassay(2010)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Angiotensin II receptor
Name:Angiotensin II receptor
Synonyms:AT1 | AT1AR | AT1BR | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:Protein
Mol. Mass.:41080.75
Organism:Homo sapiens (Human)
Description:P30556
Residue:359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
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  Blast E-value cutoff:
BDBM67184
NameBDBM67184
Synonyms:1-[3-(4-bromanyl-3,5-dimethyl-pyrazol-1-yl)propanoylamino]-3-(2-methylpropyl)thiourea | 1-[3-(4-bromo-3,5-dimethyl-pyrazol-1-yl)propanoylamino]-3-isobutyl-thiourea | 1-[3-(4-bromo-3,5-dimethylpyrazol-1-yl)propanoylamino]-3-(2-methylpropyl)thiourea | 1-[[3-(4-bromo-3,5-dimethyl-1-pyrazolyl)-1-oxopropyl]amino]-3-(2-methylpropyl)thiourea | 2-[3-(4-bromo-3,5-dimethyl-1H-pyrazol-1-yl)propanoyl]-N-isobutylhydrazinecarbothioamide | MLS000538640 | SMR000160245 | cid_1767917
TypeSmall organic molecule
Emp. Form.C13H22BrN5OS
Mol. Mass.376.316
SMILESCC(C)CNC(=S)NNC(=O)CCn1nc(C)c(Br)c1C
Structure
n/a