Reaction Details Report a problem with these data
Target
G-protein coupled receptor 35
Ligand
BDBM75859
Substrate
n/a
Meas. Tech.
SAR analysis of Antagonists of the GPR35 Receptor using an Image-Based Assay - Set 5
IC50
307±n/a nM
Citation
 PubChem, PC SAR analysis of Antagonists of the GPR35 Receptor using an Image-Based Assay - Set 5 PubChem Bioassay (2010)[AID] 
Target
Name:
G-protein coupled receptor 35
Synonyms:
G protein-coupled receptor 35 | GPR35 | GPR35_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
34085.57
Organism:
Homo sapiens (Human)
Description:
gi_33695097
Residue:
309
Sequence:
MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
  
Inhibitor
Name:
BDBM75859
Synonyms:
5-[(E)-(tert-butylthiocarbamoylhydrazono)methyl]-1-phenyl-pyrazole-4-carboxylic acid methyl ester | 5-[(E)-[[(tert-butylamino)-sulfanylidenemethyl]hydrazinylidene]methyl]-1-phenyl-4-pyrazolecarboxylic acid methyl ester | MLS-0437442.0001 | cid_9581005 | methyl 5-[(E)-(tert-butylcarbamothioylhydrazinylidene)methyl]-1-phenyl-pyrazole-4-carboxylate | methyl 5-[(E)-(tert-butylcarbamothioylhydrazinylidene)methyl]-1-phenylpyrazole-4-carboxylate
Type:
Small organic molecule
Emp. Form.:
C17H21N5O2S
Mol. Mass.:
359.446
SMILES:
COC(=O)c1cnn(c1C=NNC(=S)NC(C)(C)C)-c1ccccc1 |w:10.11|
Structure:
Search PDB for entries with ligand similarity: