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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM75885
Substrate
n/a
Meas. Tech.
Late-stage fluorescence-based counterscreen for antagonists of the G-protein coupled receptor 7 (GPR7)
IC50
9500±n/a nM
Citation
 PubChem, PC Late-stage fluorescence-based counterscreen for antagonists of the G-protein coupled receptor 7 (GPR7): cell-based dose response assay to identify antagonists of the melanin-concentrating hormone receptor 1 (MCHR1) PubChem Bioassay (2010)[AID] 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM75885
Synonyms:
5-chloranyl-4-(4-fluoranyl-2-methoxy-phenoxy)-2-(4-methylphenyl)pyridazin-3-one | 5-chloro-4-(4-fluoro-2-methoxy-phenoxy)-2-(p-tolyl)pyridazin-3-one | 5-chloro-4-(4-fluoro-2-methoxyphenoxy)-2-(4-methylphenyl)-3-pyridazinone | 5-chloro-4-(4-fluoro-2-methoxyphenoxy)-2-(4-methylphenyl)pyridazin-3-one | SR-02000000353 | SR-02000000353-1 | cid_46172925
Type:
Small organic molecule
Emp. Form.:
C18H14ClFN2O3
Mol. Mass.:
360.767
SMILES:
COc1cc(F)ccc1Oc1c(Cl)cnn(-c2ccc(C)cc2)c1=O
Structure:
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