Reaction Details Report a problem with these data
Target
Neuropeptides B/W receptor type 1
Ligand
BDBM75921
Substrate
n/a
Meas. Tech.
Late-stage fluorescence-based dose response cell-based screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7)
IC50
1200±n/a nM
Citation
 PubChem, PC Late-stage fluorescence-based dose response cell-based screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7) PubChem Bioassay (2010)[AID] 
Target
Name:
Neuropeptides B/W receptor type 1
Synonyms:
GPR7 | NPBW1_HUMAN | NPBWR1 | neuropeptides B/W receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36111.82
Organism:
Homo sapiens (Human)
Description:
gi_119607128
Residue:
328
Sequence:
MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
  
Inhibitor
Name:
BDBM75921
Synonyms:
4-[4-chloro-5-(4-methoxyphenoxy)-6-oxo-1-pyridazinyl]benzoic acid ethyl ester | 4-[4-chloro-6-keto-5-(4-methoxyphenoxy)pyridazin-1-yl]benzoic acid ethyl ester | SR-02000000451 | SR-02000000451-1 | cid_46835788 | ethyl 4-[4-chloranyl-5-(4-methoxyphenoxy)-6-oxidanylidene-pyridazin-1-yl]benzoate | ethyl 4-[4-chloro-5-(4-methoxyphenoxy)-6-oxopyridazin-1-yl]benzoate
Type:
Small organic molecule
Emp. Form.:
C20H17ClN2O5
Mol. Mass.:
400.812
SMILES:
CCOC(=O)c1ccc(cc1)-n1ncc(Cl)c(Oc2ccc(OC)cc2)c1=O
Structure:
Search PDB for entries with ligand similarity: