Reaction Details Report a problem with these data
Target
Neuropeptides B/W receptor type 1
Ligand
BDBM75925
Substrate
n/a
Meas. Tech.
Late-stage fluorescence-based dose response cell-based screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7)
IC50
12200±n/a nM
Citation
 PubChem, PC Late-stage fluorescence-based dose response cell-based screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7) PubChem Bioassay (2010)[AID] 
Target
Name:
Neuropeptides B/W receptor type 1
Synonyms:
GPR7 | NPBW1_HUMAN | NPBWR1 | neuropeptides B/W receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36111.82
Organism:
Homo sapiens (Human)
Description:
gi_119607128
Residue:
328
Sequence:
MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
  
Inhibitor
Name:
BDBM75925
Synonyms:
5-chloranyl-2-(4-propan-2-ylphenyl)-4-[4-(trifluoromethyloxy)phenoxy]pyridazin-3-one | 5-chloro-2-(4-propan-2-ylphenyl)-4-[4-(trifluoromethoxy)phenoxy]-3-pyridazinone | 5-chloro-2-(4-propan-2-ylphenyl)-4-[4-(trifluoromethoxy)phenoxy]pyridazin-3-one | 5-chloro-2-p-cumenyl-4-[4-(trifluoromethoxy)phenoxy]pyridazin-3-one | SR-02000000458 | SR-02000000458-1 | cid_46835812
Type:
Small organic molecule
Emp. Form.:
C20H16ClF3N2O3
Mol. Mass.:
424.801
SMILES:
CC(C)c1ccc(cc1)-n1ncc(Cl)c(Oc2ccc(OC(F)(F)F)cc2)c1=O
Structure:
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