Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM47114
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists
IC50
23218±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM47114
Synonyms:
MLS000089472 | N-(5-acetamido-2-methoxy-phenyl)-6-(4-methoxyphenyl)-3-methyl-imidazo[2,1-b][1,3]thiazole-2-carboxamide | N-(5-acetamido-2-methoxy-phenyl)-6-(4-methoxyphenyl)-3-methyl-imidazo[2,1-b]thiazole-2-carboxamide | N-(5-acetamido-2-methoxyphenyl)-6-(4-methoxyphenyl)-3-methyl-2-imidazo[2,1-b]thiazolecarboxamide | N-(5-acetamido-2-methoxyphenyl)-6-(4-methoxyphenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxamide | SMR000016547 | cid_3244553
Type:
Small organic molecule
Emp. Form.:
C23H22N4O4S
Mol. Mass.:
450.51
SMILES:
COc1ccc(cc1)-c1cn2c(C)c(sc2n1)C(=O)Nc1cc(NC(C)=O)ccc1OC
Structure:
Search PDB for entries with ligand similarity: