Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM50844
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists
IC50
3136±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM50844
Synonyms:
5,10-dihydro-[1,3]thiazolo[4,5-b][1,5]benzodiazepin-2-one | 5,10-dihydrothiazolo[4,5-b][1,5]benzodiazepin-2-one | MLS000113820 | SMR000057703 | cid_5310639
Type:
Small organic molecule
Emp. Form.:
C10H7N3OS
Mol. Mass.:
217.247
SMILES:
O=c1[nH]c2Nc3ccccc3N=Cc2s1 |c:12|
Structure:
Search PDB for entries with ligand similarity: