Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM75207
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists
IC50
6666±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM75207
Synonyms:
2-(5-bromanylthiophen-2-yl)-N-(3-ethoxypropyl)quinoline-4-carboxamide | 2-(5-bromo-2-thienyl)-N-(3-ethoxypropyl)cinchoninamide | 2-(5-bromo-2-thiophenyl)-N-(3-ethoxypropyl)-4-quinolinecarboxamide | 2-(5-bromothien-2-yl)-N-(3-ethoxypropyl)quinoline-4-carboxamide | 2-(5-bromothiophen-2-yl)-N-(3-ethoxypropyl)quinoline-4-carboxamide | MLS001197915 | SMR000559708 | cid_15996111
Type:
Small organic molecule
Emp. Form.:
C19H19BrN2O2S
Mol. Mass.:
419.335
SMILES:
CCOCCCNC(=O)c1cc(nc2ccccc12)-c1ccc(Br)s1
Structure:
Search PDB for entries with ligand similarity: