Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM76012
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists
IC50
5353±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM76012
Synonyms:
2-(2-Cyclopropyl-quinazolin-4-ylsulfanyl)-N-(3,5-dimethoxy-phenyl)-acetamide | 2-(2-cyclopropylquinazolin-4-yl)sulfanyl-N-(3,5-dimethoxyphenyl)acetamide | 2-(2-cyclopropylquinazolin-4-yl)sulfanyl-N-(3,5-dimethoxyphenyl)ethanamide | 2-[(2-cyclopropyl-4-quinazolinyl)thio]-N-(3,5-dimethoxyphenyl)acetamide | 2-[(2-cyclopropylquinazolin-4-yl)thio]-N-(3,5-dimethoxyphenyl)acetamide | MLS001220814 | SMR000600258 | cid_1435125
Type:
Small organic molecule
Emp. Form.:
C21H21N3O3S
Mol. Mass.:
395.475
SMILES:
COc1cc(NC(=O)CSc2nc(nc3ccccc23)C2CC2)cc(OC)c1
Structure:
Search PDB for entries with ligand similarity: