Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM76129
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay
EC50
77600±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM76129
Synonyms:
(3-butyl-2-cyclohexyl-7-methyl-6,8-dioxoisoquinolin-7-yl) propanoate | CMLD003504 | MLS000438581 | SMR000452633 | [3-butyl-2-cyclohexyl-7-methyl-6,8-bis(oxidanylidene)isoquinolin-7-yl] propanoate | cid_16745620 | propanoic acid (3-butyl-2-cyclohexyl-7-methyl-6,8-dioxo-7-isoquinolinyl) ester | propionic acid (3-butyl-2-cyclohexyl-6,8-diketo-7-methyl-7-isoquinolyl) ester
Type:
Small organic molecule
Emp. Form.:
C23H31NO4
Mol. Mass.:
385.4965
SMILES:
CCCCC1=CC2=CC(=O)C(C)(OC(=O)CC)C(=O)C2=CN1C1CCCCC1 |c:20,t:4,6|
Structure:
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