Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM76132
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay
EC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM76132
Synonyms:
MLS001210138 | N-(2,4-Dimethoxy-benzylidene)-N'-(2,6-dimethyl-quinolin-4-yl)-hydrazine | N-[(2,4-dimethoxyphenyl)methylideneamino]-2,6-dimethyl-4-quinolinamine | N-[(2,4-dimethoxyphenyl)methylideneamino]-2,6-dimethyl-quinolin-4-amine | N-[(2,4-dimethoxyphenyl)methylideneamino]-2,6-dimethylquinolin-4-amine | SMR000517665 | [(2,4-dimethoxybenzylidene)amino]-(2,6-dimethyl-4-quinolyl)amine | cid_3141487
Type:
Small organic molecule
Emp. Form.:
C20H21N3O2
Mol. Mass.:
335.3996
SMILES:
COc1ccc(CN=Nc2cc(C)nc3ccc(C)cc23)c(OC)c1 |w:8.8|
Structure:
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