Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM76136
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay
EC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM76136
Synonyms:
MLS001125519 | N-[(3-methylsulfanylphenyl)carbamothioyl]-3-phenyl-propanamide | N-[(3-methylsulfanylphenyl)carbamothioyl]-3-phenylpropanamide | N-[[3-(methylthio)anilino]-sulfanylidenemethyl]-3-phenylpropanamide | N-[[3-(methylthio)phenyl]thiocarbamoyl]-3-phenyl-propionamide | SMR000668634 | cid_1302078
Type:
Small organic molecule
Emp. Form.:
C17H18N2OS2
Mol. Mass.:
330.468
SMILES:
CSc1cccc(NC(=S)NC(=O)CCc2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: