Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM76139
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay
EC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM76139
Synonyms:
6-(4-methylpiperidin-1-yl)sulfonyl-2-(4-phenylpiperazin-1-yl)quinoline | 6-(4-methylpiperidino)sulfonyl-2-(4-phenylpiperazino)quinoline | 6-[(4-methyl-1-piperidinyl)sulfonyl]-2-(4-phenyl-1-piperazinyl)quinoline | MLS001095136 | SMR000630335 | cid_16024792
Type:
Small organic molecule
Emp. Form.:
C25H30N4O2S
Mol. Mass.:
450.596
SMILES:
CC1CCN(CC1)S(=O)(=O)c1ccc2nc(ccc2c1)N1CCN(CC1)c1ccccc1
Structure:
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