Reaction Details Report a problem with these data
Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM60497
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay
IC50
9920±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM60497
Synonyms:
4-Methyl-furazan-3-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide | MLS000554508 | N-[(3,4-diketocyclohexa-1,5-dien-1-yl)methyleneamino]-4-methyl-2,5-dihydrofurazan-3-carboxamide | N-[(3,4-dioxo-1-cyclohexa-1,5-dienyl)methylideneamino]-4-methyl-2,5-dihydro-1,2,5-oxadiazole-3-carboxamide | N-[(3,4-dioxocyclohexa-1,5-dien-1-yl)methylideneamino]-4-methyl-2,5-dihydro-1,2,5-oxadiazole-3-carboxamide | N-[[3,4-bis(oxidanylidene)cyclohexa-1,5-dien-1-yl]methylideneamino]-4-methyl-2,5-dihydro-1,2,5-oxadiazole-3-carboxamide | SMR000171281 | cid_6744580
Type:
Small organic molecule
Emp. Form.:
C11H10N4O4
Mol. Mass.:
262.2215
SMILES:
CC1NON=C1C(=O)NN=CC1=CC(=O)C(=O)C=C1 |w:9.9,c:4,18,t:12|
Structure:
Search PDB for entries with ligand similarity: