Reaction Details Report a problem with these data
Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM76178
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay
IC50
8660±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM76178
Synonyms:
3-[[anilino(oxo)methyl]amino]-4-[4-(2-fluorophenyl)-1-piperazinyl]benzoic acid ethyl ester | 4-[4-(2-fluorophenyl)piperazino]-3-(phenylcarbamoylamino)benzoic acid ethyl ester | MLS000584003 | SMR000206989 | cid_12004838 | ethyl 3-[(anilinocarbonyl)amino]-4-[4-(2-fluorophenyl)piperazin-1-yl]benzoate | ethyl 4-[4-(2-fluorophenyl)piperazin-1-yl]-3-(phenylcarbamoylamino)benzoate
Type:
Small organic molecule
Emp. Form.:
C26H27FN4O3
Mol. Mass.:
462.516
SMILES:
CCOC(=O)c1ccc(N2CCN(CC2)c2ccccc2F)c(NC(=O)Nc2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: