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Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM76241
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay
IC50
9040±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM76241
Synonyms:
5-[2-(3,4-dihydroxyphenyl)-2-oxoethyl]sulfanyl-2-phenyl-8,9,10,11-tetrahydro-7H-pyrazolo[1,2]pyrimido[3,5-a]azepin-1-one | 5-[2-[3,4-bis(oxidanyl)phenyl]-2-oxidanylidene-ethyl]sulfanyl-2-phenyl-8,9,10,11-tetrahydro-7H-pyrazolo[1,2]pyrimido[3,5-a]azepin-1-one | 5-[[2-(3,4-dihydroxyphenyl)-2-keto-ethyl]thio]-2-phenyl-8,9,10,11-tetrahydro-7H-pyrazolo[1,2]pyrimid[3,5-a]azepin-1-one | 5-[[2-(3,4-dihydroxyphenyl)-2-oxoethyl]thio]-2-phenyl-8,9,10,11-tetrahydro-7H-pyrazolo[1,2]pyrimido[3,5-a]azepin-1-one | MLS002156135 | SMR001238644 | cid_2090567
Type:
Small organic molecule
Emp. Form.:
C24H22N4O4S
Mol. Mass.:
462.521
SMILES:
Oc1ccc(cc1O)C(=O)CSc1nc2nn(-c3ccccc3)c(=O)c2c2CCCCCn12
Structure:
Search PDB for entries with ligand similarity: