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Target
Intestinal-type alkaline phosphatase
Ligand
BDBM48868
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule inhibitors of human intestinal alkaline phosphatase via a luminescent assay - Set 2
IC50
10200±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of human intestinal alkaline phosphatase via a luminescent assay - Set 2 PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM48868
Synonyms:
1-ethyl-2-[(E)-2-(1H-indol-3-yl)ethenyl]-6-methyl-quinolin-1-ium;iodide | 1-ethyl-2-[(E)-2-(1H-indol-3-yl)ethenyl]-6-methylquinolin-1-ium;iodide | 1-ethyl-2-[(E)-2-(1H-indol-3-yl)vinyl]-6-methyl-quinolin-1-ium;iodide | 1-ethyl-2-[(E)-2-(1H-indol-3-yl)vinyl]-6-methylquinolinium | MLS000724364 | SMR000305958 | cid_16195322
Type:
Small organic molecule
Emp. Form.:
C22H21N2
Mol. Mass.:
313.415
SMILES:
CC[n+]1c(\C=C\c2c[nH]c3ccccc23)ccc2cc(C)ccc12
Structure:
Search PDB for entries with ligand similarity: