Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM71573
Substrate
n/a
Meas. Tech.
SAR analysis of Antagonists of the Kappa Opioid Receptor (KOR) using an Image-Based Assay - Set 3
IC50
173±n/a nM
Citation
 PubChem, PC SAR analysis of Antagonists of the Kappa Opioid Receptor (KOR) using an Image-Based Assay - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM71573
Synonyms:
4-[[(4-ethylphenyl)sulfonylamino]methyl]-N-[2-[(4-methylphenyl)methyl-propan-2-yl-amino]ethyl]benzamide | 4-[[(4-ethylphenyl)sulfonylamino]methyl]-N-[2-[(4-methylphenyl)methyl-propan-2-ylamino]ethyl]benzamide | 4-[[(4-ethylphenyl)sulfonylamino]methyl]-N-[2-[isopropyl-(4-methylbenzyl)amino]ethyl]benzamide | KSC-5-271B | KUC104153N | cid_44608031
Type:
Small organic molecule
Emp. Form.:
C29H37N3O3S
Mol. Mass.:
507.687
SMILES:
CCc1ccc(cc1)S(=O)(=O)NCc1ccc(cc1)C(=O)NCCN(Cc1ccc(C)cc1)C(C)C
Structure:
Search PDB for entries with ligand similarity: