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Target
Kappa-type opioid receptor
Ligand
BDBM71577
Substrate
n/a
Meas. Tech.
SAR analysis of Antagonists of the Kappa Opioid Receptor (KOR) using an Image-Based Assay - Set 3
IC50
470±n/a nM
Citation
 PubChem, PC SAR analysis of Antagonists of the Kappa Opioid Receptor (KOR) using an Image-Based Assay - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM71577
Synonyms:
KSC-11-32-1 | KUC104157N | N-[2-[benzyl(butan-2-yl)amino]ethyl]-4-[[(4-ethylphenyl)sulfonylamino]methyl]benzamide | N-[2-[benzyl(sec-butyl)amino]ethyl]-4-[[(4-ethylphenyl)sulfonylamino]methyl]benzamide | N-[2-[butan-2-yl-(phenylmethyl)amino]ethyl]-4-[[(4-ethylphenyl)sulfonylamino]methyl]benzamide | cid_44608027
Type:
Small organic molecule
Emp. Form.:
C29H37N3O3S
Mol. Mass.:
507.687
SMILES:
CCC(C)N(CCNC(=O)c1ccc(CNS(=O)(=O)c2ccc(CC)cc2)cc1)Cc1ccccc1
Structure:
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