Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM71595
Substrate
n/a
Meas. Tech.
SAR analysis of Antagonists of the Kappa Opioid Receptor (KOR) using an Image-Based Assay - Set 3
IC50
>32000±n/a nM
Citation
 PubChem, PC SAR analysis of Antagonists of the Kappa Opioid Receptor (KOR) using an Image-Based Assay - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM71595
Synonyms:
2-(4-oxidanylidenepyrrolo[1,2-a]quinoxalin-5-yl)-N-[3-[4-(phenylmethyl)piperazin-1-yl]propyl]ethanamide | 2-(4-oxo-5-pyrrolo[1,2-a]quinoxalinyl)-N-[3-[4-(phenylmethyl)-1-piperazinyl]propyl]acetamide | KSC-1-177 | KUC104208N | N-[3-(4-benzylpiperazin-1-yl)propyl]-2-(4-oxopyrrolo[1,2-a]quinoxalin-5-yl)acetamide | N-[3-(4-benzylpiperazino)propyl]-2-(4-ketopyrrolo[1,2-a]quinoxalin-5-yl)acetamide | cid_22522557
Type:
Small organic molecule
Emp. Form.:
C27H31N5O2
Mol. Mass.:
457.5673
SMILES:
O=C(Cn1c2ccccc2n2cccc2c1=O)NCCCN1CCN(Cc2ccccc2)CC1
Structure:
Search PDB for entries with ligand similarity: