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Target
Delta-type opioid receptor
Ligand
BDBM75581
Substrate
n/a
Meas. Tech.
SAR Analysis of Antagonists of the DOR Receptor using an Image-Based Assay - Set 3
IC50
>32000±n/a nM
Citation
 PubChem, PC SAR Analysis of Antagonists of the DOR Receptor using an Image-Based Assay - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM75581
Synonyms:
2-(4-methylphenyl)sulfonyl-N-[2-[(phenylmethyl)-propan-2-yl-amino]ethyl]-3,4-dihydro-1H-isoquinoline-7-carboxamide | 2-(4-methylphenyl)sulfonyl-N-[2-[(phenylmethyl)-propan-2-ylamino]ethyl]-3,4-dihydro-1H-isoquinoline-7-carboxamide | KSC-11-165-1 | KUC105602N | N-[2-[benzyl(isopropyl)amino]ethyl]-2-tosyl-3,4-dihydro-1H-isoquinoline-7-carboxamide | N-[2-[benzyl(propan-2-yl)amino]ethyl]-2-(4-methylphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-7-carboxamide | cid_45479164
Type:
Small organic molecule
Emp. Form.:
C29H35N3O3S
Mol. Mass.:
505.672
SMILES:
CC(C)N(CCNC(=O)c1ccc2CCN(Cc2c1)S(=O)(=O)c1ccc(C)cc1)Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: