Reaction Details Report a problem with these data
Target
NACHT, LRR and PYD domains-containing protein 1
Ligand
BDBM71174
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for the identification of inhibitors of NALP1 in yeast using a luminescent assay
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for the identification of inhibitors of NALP1 in yeast using a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
NACHT, LRR and PYD domains-containing protein 1
Synonyms:
CARD7 | DEFCAP | KIAA0926 | NAC | NACHT, LRR and PYD domains-containing protein 1 isoform 1 | NALP1 | NLRP1 | NLRP1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
165873.33
Organism:
Homo sapiens (Human)
Description:
Q9C000
Residue:
1473
Sequence:
MAGGAWGRLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWDLALHTWEQMGLRSLCAQAQEGAGHSPSFPYSPSEPHLGSPSQPTSTAVLMPWIHELPAGCTQGSERRVLRQLPDTSGRRWREISASLLYQALPSSPDHESPSQESPNAPTSTAVLGSWGSPPQPSLAPREQEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHPWEPSVRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSWPDYVEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEHPIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHSNCIIDLEKTLEAYGIHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQGRNLMQWVPSLQLLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKLLDVSKIFPIAEIAEESSPEVVPVELLCVPSPASQGDLHTKPLGTDDDFWGPTGPVATEVVDKEKNLYRVHFPVAGSYRWPNTGLCFVMREAVTVEIEFCVWDQFLGEINPQHSWMVAGPLLDIKAEPGAVEAVHLPHFVALQGGHVDTSLFQMAHFKEEGMLLEKPARVELHHIVLENPSFSPLGVLLKMIHNALRFIPVTSVVLLYHRVHPEEVTFHLYLIPSDCSIRKAIDDLEMKFQFVRIHKPPPLTPLYMGCRYTVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVWEALVKPGDLMPATTLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKGSKKGLLPLSS
  
Inhibitor
Name:
BDBM71174
Synonyms:
4-(1-benzimidazolyl)-1-methyl-3-nitro-2-quinolinone | 4-(benzimidazol-1-yl)-1-methyl-3-nitro-carbostyril | 4-(benzimidazol-1-yl)-1-methyl-3-nitro-quinolin-2-one | 4-(benzimidazol-1-yl)-1-methyl-3-nitroquinolin-2-one | 4-Benzoimidazol-1-yl-1-methyl-3-nitro-1H-quinolin-2-one | MLS001044344 | SMR000424894 | cid_769909
Type:
Small organic molecule
Emp. Form.:
C17H12N4O3
Mol. Mass.:
320.3022
SMILES:
Cn1c2ccccc2c(c([N+]([O-])=O)c1=O)-n1cnc2ccccc12 |(7.08,4.83,;7.08,3.29,;8.41,2.52,;9.79,3.35,;11.19,2.56,;11.19,.95,;9.79,.16,;8.41,.98,;7.08,.21,;5.75,.98,;4.41,.21,;3.08,.98,;4.41,-1.33,;5.75,2.52,;4.41,3.29,;7.08,-1.33,;5.84,-2.22,;6.31,-3.68,;7.84,-3.69,;8.87,-4.83,;10.38,-4.52,;10.86,-3.05,;9.83,-1.91,;8.32,-2.22,)|
Structure:
Search PDB for entries with ligand similarity: