Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM55601
Substrate
n/a
Meas. Tech.
Dose Response Confirmation of compounds that inhibit VHR1 in Fluorescent Assay
IC50
730±n/a nM
Citation
 PubChem, PC Dose Response Confirmation of compounds that inhibit VHR1 in Fluorescent Assay PubChem Bioassay (2010)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM55601
Synonyms:
1-(2,3-dihydroindol-1-yl)-2-[[(5E)-4-(4-ethoxyphenyl)-5-(3-indolylidene)-1H-1,2,4-triazol-3-yl]thio]ethanone | 1-(2,3-dihydroindol-1-yl)-2-[[(5E)-4-(4-ethoxyphenyl)-5-indol-3-ylidene-1H-1,2,4-triazol-3-yl]sulfanyl]ethanone | 1-indolin-1-yl-2-[[(5E)-5-indol-3-ylidene-4-p-phenetyl-1H-1,2,4-triazol-3-yl]thio]ethanone | MLS000724638 | SMR000237500 | cid_6161440
Type:
Small organic molecule
Emp. Form.:
C28H25N5O2S
Mol. Mass.:
495.595
SMILES:
CCOc1ccc(cc1)-n1c(SCC(=O)N2CCc3ccccc23)nnc1-c1c[nH]c2ccccc12
Structure:
Search PDB for entries with ligand similarity: