Reaction Details Report a problem with these data
Target
Caspase-1
Ligand
BDBM61402
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen.
IC50
15900±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen. PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-1
Synonyms:
CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Homo sapiens (Human)
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
  
Inhibitor
Name:
BDBM61402
Synonyms:
(Z)-2-butenedioic acid;2-(2,2-dicyclohexylethyl)piperidine | (Z)-but-2-enedioic acid;2-(2,2-dicyclohexylethyl)piperidine | 2-(2,2-dicyclohexylethyl)piperidine;maleic acid | 2-[2,2-DICYCLOHEXYLETHYL]PIPERIDINE MALEATE SALT | CHEMBL75880 | MLS000028601 | Perhexiline | SMR000058713 | cid_5284439 | perhexiline maleate
Type:
Small organic molecule
Emp. Form.:
C19H35N
Mol. Mass.:
277.4879
SMILES:
C(C(C1CCCCC1)C1CCCCC1)C1CCCCN1
Structure:
Search PDB for entries with ligand similarity: