Reaction Details Report a problem with these data
Target
Caspase-1
Ligand
BDBM76312
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen.
IC50
2980±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen. PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-1
Synonyms:
CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Homo sapiens (Human)
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
  
Inhibitor
Name:
BDBM76312
Synonyms:
1-(4-acetylphenyl)-3-(4-chlorophenyl)urea | 1-(4-chlorophenyl)-3-(4-ethanoylphenyl)urea | MLS000532184 | N-(4-acetylphenyl)-N'-(4-chlorophenyl)urea | SMR000137125 | cid_721943
Type:
Small organic molecule
Emp. Form.:
C15H13ClN2O2
Mol. Mass.:
288.729
SMILES:
CC(=O)c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1
Structure:
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