Reaction Details Report a problem with these data
Target
Caspase-1
Ligand
BDBM67953
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen.
IC50
5130±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen. PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-1
Synonyms:
CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Homo sapiens (Human)
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
  
Inhibitor
Name:
BDBM67953
Synonyms:
1-(3-chlorophenyl)-3-(1-phenyltetrazol-5-yl)sulfanylpyrrolidine-2,5-dione | 1-(3-chlorophenyl)-3-[(1-phenyl-1,2,3,4-tetrazol-5-yl)sulfanyl]pyrrolidine-2,5-dione | 1-(3-chlorophenyl)-3-[(1-phenyl-1H-tetrazol-5-yl)thio]-2,5-pyrrolidinedione | 1-(3-chlorophenyl)-3-[(1-phenyl-5-tetrazolyl)thio]pyrrolidine-2,5-dione | 1-(3-chlorophenyl)-3-[(1-phenyltetrazol-5-yl)thio]pyrrolidine-2,5-quinone | MLS000580504 | SMR000199391 | cid_2950397
Type:
Small organic molecule
Emp. Form.:
C17H12ClN5O2S
Mol. Mass.:
385.827
SMILES:
Oc1cc(Sc2nnnn2-c2ccccc2)c(O)n1-c1cccc(Cl)c1
Structure:
Search PDB for entries with ligand similarity: