Reaction Details Report a problem with these data
Target
Caspase-1
Ligand
BDBM76325
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen.
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen. PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-1
Synonyms:
CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Homo sapiens (Human)
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
  
Inhibitor
Name:
BDBM76325
Synonyms:
(3Z)-5-(3,4-dimethoxyphenyl)-3-(3-pyridinylmethylidene)-2-furanone | (3Z)-5-(3,4-dimethoxyphenyl)-3-(3-pyridylmethylene)furan-2-one | (3Z)-5-(3,4-dimethoxyphenyl)-3-(pyridin-3-ylmethylidene)furan-2-one | 5-(3,4-dimethoxyphenyl)-3-(3-pyridinylmethylene)-2(3H)-furanone | MLS000701093 | SMR000226349 | cid_5407596
Type:
Small organic molecule
Emp. Form.:
C18H15NO4
Mol. Mass.:
309.316
SMILES:
COc1ccc(cc1OC)C1=C\C(=C\c2cccnc2)C(=O)O1 |t:11|
Structure:
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