Reaction Details Report a problem with these data
Target
Caspase-1
Ligand
BDBM76328
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen.
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen. PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-1
Synonyms:
CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Homo sapiens (Human)
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
  
Inhibitor
Name:
BDBM76328
Synonyms:
MLS000681264 | N-(2-methoxy-5-methyl-phenyl)-4-[(4-phenylpiperazin-1-yl)methyl]benzamide | N-(2-methoxy-5-methyl-phenyl)-4-[(4-phenylpiperazino)methyl]benzamide | N-(2-methoxy-5-methylphenyl)-4-[(4-phenyl-1-piperazinyl)methyl]benzamide | N-(2-methoxy-5-methylphenyl)-4-[(4-phenylpiperazin-1-yl)methyl]benzamide | SMR000269053 | cid_2897124
Type:
Small organic molecule
Emp. Form.:
C26H29N3O2
Mol. Mass.:
415.5274
SMILES:
COc1ccc(C)cc1NC(=O)c1ccc(CN2CCN(CC2)c2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: