Reaction Details Report a problem with these data
Target
Caspase-1
Ligand
BDBM76331
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen.
IC50
7100±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen. PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-1
Synonyms:
CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Homo sapiens (Human)
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
  
Inhibitor
Name:
BDBM76331
Synonyms:
1-(3,6-dichloro-9-carbazolyl)-3-(1-piperidinyl)-2-propanol | 1-(3,6-dichlorocarbazol-9-yl)-3-piperidin-1-ylpropan-2-ol | 1-(3,6-dichlorocarbazol-9-yl)-3-piperidino-propan-2-ol | 1-[3,6-bis(chloranyl)carbazol-9-yl]-3-piperidin-1-yl-propan-2-ol | MLS001181479 | SMR000567242 | cid_2802138
Type:
Small organic molecule
Emp. Form.:
C20H22Cl2N2O
Mol. Mass.:
377.307
SMILES:
OC(CN1CCCCC1)Cn1c2ccc(Cl)cc2c2cc(Cl)ccc12
Structure:
Search PDB for entries with ligand similarity: