Target
Caspase-1
Ligand
BDBM64746
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen.
IC50
6440±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen. PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-1
Synonyms:
CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Homo sapiens (Human)
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
  
Inhibitor
Name:
BDBM64746
Synonyms:
3-[1-(2-chloranyl-6-fluoranyl-phenyl)-2-nitro-ethyl]-2-methyl-indolizine | 3-[1-(2-chloro-6-fluoro-phenyl)-2-nitro-ethyl]-2-methyl-indolizine | 3-[1-(2-chloro-6-fluorophenyl)-2-nitroethyl]-2-methylindolizine | MLS001175213 | SMR000590891 | cid_4680117
Type:
Small organic molecule
Emp. Form.:
C17H14ClFN2O2
Mol. Mass.:
332.757
SMILES:
Cc1cc2ccccn2c1C(C[N+]([O-])=O)c1c(F)cccc1Cl
Structure:
Search PDB for entries with ligand similarity: