Target
Intestinal-type alkaline phosphatase
Ligand
BDBM59274
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS activators of Mouse Intestinal Alkaline Phosphatase using Human Intestinal Alkaline Phosphatase
EC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS activators of Mouse Intestinal Alkaline Phosphatase using Human Intestinal Alkaline Phosphatase PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM59274
Synonyms:
2-{4-[3-(4-Isopropyl-phenyl)-ureido]-piperidin-1-yl}-N-naphthalen-1-yl-acetamide | MLS000122731 | N-(1-naphthalenyl)-2-[4-[[oxo-(4-propan-2-ylanilino)methyl]amino]-1-piperidinyl]acetamide | N-(1-naphthyl)-2-[4-(p-cumenylcarbamoylamino)piperidino]acetamide | N-naphthalen-1-yl-2-[4-[(4-propan-2-ylphenyl)carbamoylamino]piperidin-1-yl]acetamide | N-naphthalen-1-yl-2-[4-[(4-propan-2-ylphenyl)carbamoylamino]piperidin-1-yl]ethanamide | SMR000120117 | cid_3220891
Type:
Small organic molecule
Emp. Form.:
C27H32N4O2
Mol. Mass.:
444.5686
SMILES:
CC(C)c1ccc(NC(=O)NC2CCN(CC(=O)Nc3cccc4ccccc34)CC2)cc1
Structure:
Search PDB for entries with ligand similarity: