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Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM59309
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase
IC50
69500±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM59309
Synonyms:
1-[(2-ethyl-4-hydroxy-1-oxo-5-propoxypentyl)amino]-3-phenylthiourea | 1-[(2-ethyl-4-hydroxy-5-propoxy-pentanoyl)amino]-3-phenyl-thiourea | 1-[(2-ethyl-4-hydroxy-5-propoxypentanoyl)amino]-3-phenylthiourea | 1-[(2-ethyl-4-oxidanyl-5-propoxy-pentanoyl)amino]-3-phenyl-thiourea | MLS000587172 | SMR000211181 | cid_3125279
Type:
Small organic molecule
Emp. Form.:
C17H27N3O3S
Mol. Mass.:
353.48
SMILES:
CCCOCC(O)CC(CC)C(=O)NNC(=S)Nc1ccccc1
Structure:
Search PDB for entries with ligand similarity: