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Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM75624
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase
EC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM75624
Synonyms:
4-Bromo-2H-pyrazole-3-carboxylic acid (2-hydroxy-5-methyl-benzylidene)-hydrazide | 4-bromanyl-N'-[(E)-(3-methyl-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]-1H-pyrazole-5-carbohydrazide | 4-bromo-N'-[(E)-(3-methyl-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-1H-pyrazole-5-carbohydrazide | 4-bromo-N'-[(E)-(3-methyl-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-1H-pyrazole-5-carbohydrazide | 4-bromo-N'-[(E)-(6-keto-3-methyl-cyclohexa-2,4-dien-1-ylidene)methyl]-1H-pyrazole-5-carbohydrazide | MLS000555044 | SMR000171215 | cid_5404589
Type:
Small organic molecule
Emp. Form.:
C12H11BrN4O2
Mol. Mass.:
323.145
SMILES:
Cc1ccc(O)c(C=NNC(=O)c2[nH]ncc2Br)c1 |w:8.8|
Structure:
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