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Target
Intestinal-type alkaline phosphatase
Ligand
BDBM76230
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS inhibitors of Mouse Intestinal Alkaline Phosphatase using Human Intestinal Alkaline Phosphatase
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS inhibitors of Mouse Intestinal Alkaline Phosphatase using Human Intestinal Alkaline Phosphatase PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM76230
Synonyms:
2-[(3-methyl-1,2-oxazol-5-yl)methyl]-5-phenyl-N-[[3-(trifluoromethyl)phenyl]methyl]pyrazole-3-carboxamide | 2-[(3-methyl-5-isoxazolyl)methyl]-5-phenyl-N-[[3-(trifluoromethyl)phenyl]methyl]-3-pyrazolecarboxamide | 2-[(3-methylisoxazol-5-yl)methyl]-5-phenyl-N-[3-(trifluoromethyl)benzyl]pyrazole-3-carboxamide | MLS001143217 | SMR001196030 | cid_24980476
Type:
Small organic molecule
Emp. Form.:
C23H19F3N4O2
Mol. Mass.:
440.4178
SMILES:
Cc1cc(Cn2nc(cc2C(=O)NCc2cccc(c2)C(F)(F)F)-c2ccccc2)on1
Structure:
Search PDB for entries with ligand similarity: