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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM52820
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase.
EC50
21400±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM52820
Synonyms:
2-(3,5-Dimethyl-pyrazol-1-yl)-4-[N'-(4,6-dimethyl-pyrimidin-2-yl)-hydrazino]-pyrimidine-5-carboxylic acid ethyl ester | 2-(3,5-dimethyl-1-pyrazolyl)-4-[(4,6-dimethyl-2-pyrimidinyl)hydrazo]-5-pyrimidinecarboxylic acid ethyl ester | 2-(3,5-dimethylpyrazol-1-yl)-4-[N'-(4,6-dimethylpyrimidin-2-yl)hydrazino]pyrimidine-5-carboxylic acid ethyl ester | MLS000333180 | SMR000436546 | cid_1980481 | ethyl 2-(3,5-dimethylpyrazol-1-yl)-4-[2-(4,6-dimethylpyrimidin-2-yl)hydrazinyl]pyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H22N8O2
Mol. Mass.:
382.4197
SMILES:
CCOC(=O)c1cnc(nc1NNc1nc(C)cc(C)n1)-n1nc(C)cc1C
Structure:
Search PDB for entries with ligand similarity: