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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM75660
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase.
EC50
45000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM75660
Synonyms:
(2E)-3-(5-bromanylthiophen-2-yl)-2-(3-methyl-1H-benzimidazol-2-ylidene)-3-oxidanylidene-propanenitrile | (2E)-3-(5-bromo-2-thienyl)-3-keto-2-(3-methyl-1H-benzimidazol-2-ylidene)propionitrile | (2E)-3-(5-bromo-2-thiophenyl)-2-(3-methyl-1H-benzimidazol-2-ylidene)-3-oxopropanenitrile | (2E)-3-(5-bromothiophen-2-yl)-2-(3-methyl-1H-benzimidazol-2-ylidene)-3-oxopropanenitrile | MLS001167394 | SMR000640730 | cid_5999922
Type:
Small organic molecule
Emp. Form.:
C15H10BrN3OS
Mol. Mass.:
360.228
SMILES:
Cn1c(nc2ccccc12)C(C#N)C(=O)c1ccc(Br)s1
Structure:
Search PDB for entries with ligand similarity: