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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM75669
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase.
EC50
3890±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM75669
Synonyms:
5-(5-methyl-2-furanyl)-N'-[(E)-(6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-1H-pyrazole-3-carbohydrazide | 5-(5-methylfuran-2-yl)-N'-[(E)-(6-oxidanylidenecyclohexa-2,4-dien-1-ylidene)methyl]-1H-pyrazole-3-carbohydrazide | 5-(5-methylfuran-2-yl)-N'-[(E)-(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]-1H-pyrazole-3-carbohydrazide | MLS000912208 | N'-[(E)-(6-ketocyclohexa-2,4-dien-1-ylidene)methyl]-5-(5-methyl-2-furyl)-1H-pyrazole-3-carbohydrazide | SMR000619913 | cid_5395275
Type:
Small organic molecule
Emp. Form.:
C16H14N4O3
Mol. Mass.:
310.3074
SMILES:
Cc1ccc(o1)-c1cc([nH]n1)C(=O)NN=Cc1ccccc1O |w:14.15|
Structure:
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