Reaction Details Report a problem with these data
Target
Alkaline phosphatase, germ cell type
Ligand
BDBM75660
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase
EC50
62200±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, germ cell type
Synonyms:
ALPG | ALPPL | ALPPL2 | Alkaline phosphatase placental-like | PPBN_HUMAN | placental-like alkaline phosphatase preproprotein
Type:
PROTEIN
Mol. Mass.:
57374.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_29964
Residue:
532
Sequence:
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP
  
Inhibitor
Name:
BDBM75660
Synonyms:
(2E)-3-(5-bromanylthiophen-2-yl)-2-(3-methyl-1H-benzimidazol-2-ylidene)-3-oxidanylidene-propanenitrile | (2E)-3-(5-bromo-2-thienyl)-3-keto-2-(3-methyl-1H-benzimidazol-2-ylidene)propionitrile | (2E)-3-(5-bromo-2-thiophenyl)-2-(3-methyl-1H-benzimidazol-2-ylidene)-3-oxopropanenitrile | (2E)-3-(5-bromothiophen-2-yl)-2-(3-methyl-1H-benzimidazol-2-ylidene)-3-oxopropanenitrile | MLS001167394 | SMR000640730 | cid_5999922
Type:
Small organic molecule
Emp. Form.:
C15H10BrN3OS
Mol. Mass.:
360.228
SMILES:
Cn1c(nc2ccccc12)C(C#N)C(=O)c1ccc(Br)s1
Structure:
Search PDB for entries with ligand similarity: