Reaction Details Report a problem with these data
Target
Alkaline phosphatase, germ cell type
Ligand
BDBM60983
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase
IC50
15500±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, germ cell type
Synonyms:
ALPG | ALPPL | ALPPL2 | Alkaline phosphatase placental-like | PPBN_HUMAN | placental-like alkaline phosphatase preproprotein
Type:
PROTEIN
Mol. Mass.:
57374.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_29964
Residue:
532
Sequence:
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP
  
Inhibitor
Name:
BDBM60983
Synonyms:
(E)-2-(3,4-dihydroxybenzoyl)-3-(4-hydroxy-3-iodo-5-methoxyphenyl)prop-2-enenitrile | (E)-2-[(3,4-dihydroxyphenyl)-oxomethyl]-3-(4-hydroxy-3-iodo-5-methoxyphenyl)-2-propenenitrile | (E)-2-[3,4-bis(oxidanyl)phenyl]carbonyl-3-(3-iodanyl-5-methoxy-4-oxidanyl-phenyl)prop-2-enenitrile | (E)-3-(4-hydroxy-3-iodo-5-methoxy-phenyl)-2-protocatechuoyl-acrylonitrile | I-OMe-Tyrphostin AG 538 | MLS002153417 | SMR001230793 | cid_5353685
Type:
Small organic molecule
Emp. Form.:
C17H12INO5
Mol. Mass.:
437.1854
SMILES:
COc1cc(\C=C(/C#N)C(=O)c2ccc(O)c(O)c2)cc(I)c1O
Structure:
Search PDB for entries with ligand similarity: