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Target
Caspase-3
Ligand
BDBM61226
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM61226
Synonyms:
3,4-dimethyl-N-[2-oxidanyl-1,3-bis(oxidanylidene)inden-2-yl]benzamide | MLS000830217 | N-(2-hydroxy-1,3-diketo-indan-2-yl)-3,4-dimethyl-benzamide | N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-3,4-dimethylbenzamide | N-(2-hydroxy-1,3-dioxo-2-indenyl)-3,4-dimethylbenzamide | N-(2-hydroxy-1,3-dioxoinden-2-yl)-3,4-dimethylbenzamide | SMR000458138 | cid_2810379
Type:
Small organic molecule
Emp. Form.:
C18H15NO4
Mol. Mass.:
309.316
SMILES:
Cc1ccc(cc1C)C(=O)NC1(O)C(=O)c2ccccc2C1=O
Structure:
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