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Target
Caspase-3
Ligand
BDBM76674
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay
IC50
1590±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM76674
Synonyms:
4-(4-Chloro-phenylazo)-3-methyl-5-oxo-4,5-dihydro-pyrazole-1-carbothioic acid amide | 4-(4-chlorophenyl)azo-3-methyl-5-oxo-4H-pyrazole-1-carbothioamide | 4-(4-chlorophenyl)azo-5-keto-3-methyl-2-pyrazoline-1-carbothioamide | 4-[(4-chlorophenyl)diazenyl]-3-methyl-5-oxidanylidene-4H-pyrazole-1-carbothioamide | 4-[(4-chlorophenyl)diazenyl]-3-methyl-5-oxo-4H-pyrazole-1-carbothioamide | MLS001202823 | SMR000513810 | cid_3103951
Type:
Small organic molecule
Emp. Form.:
C11H10ClN5OS
Mol. Mass.:
295.748
SMILES:
Cc1[nH]n(C(N)=S)c(=O)c1N=Nc1ccc(Cl)cc1 |w:10.10|
Structure:
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